Gamma knife radiosurgery for trigeminal schwannomas: A systematic review and meta-analysis

As the second most common intracranial schwannomas and benign nerve tumor originating from the fifth cranial nerve, trigeminal schwannomas (TSs) have an insidious onset and slow growth [1–4]. TSs are usually located at Meckel’s cave, posterior fossa, or cavernous sinus and overlap multiple cranial fossae and can lead to variable symptoms, including facial numbness, facial pain, facial weakness, diplopia, headache and etc.[5,6] Due to its rarity and its diversification of clinical symptoms and signs, there has still been no standardized treatment for TS [7–10].