Primary intracranial malignant melanomas in solitary type: a tertiary center experience

Malignant melanomas arising in the brain are rare but aggressive. These tumors arise from melanocytes of the leptomeninges, which developed from melanoblasts in the neural crest [1]. Few case reports on these tumors could be reviewed by Medline or PubMed. Most of the reviewed cases about intracranial melanoma referred to metastatic melanomas [2]. The most common primary sites were cutaneous or mucosal lesions. One article reported that among 67 central nervous system (CNS) melanoma reports, 53 cases referred to tumors from the cerebral area [3].